
VayneCounters

P

Q

W

E

R
Optimized Vayne builds, runes, skill orders, and matchup strategies — plus expert tips and guides for every Vayne matchup. Brought to you by League of Matchups, your source for counter-picking insights.
Best Picks vs Vayne
These picks are strong against Vayne at many stages of the game. Champs listed by highest win rate matchups vs Vayne in NA Diamond +.
Sona57.81% WR
365 games
Senna52.72% WR
184 games
Lulu52.59% WR
540 games
Bard52.30% WR
348 games
Milio52.00% WR
475 games
Rakan51.89% WR
212 games
Zilean51.85% WR
135 games
Janna51.81% WR
276 games
Taric51.38% WR
109 games
Nami50.66% WR
608 games
Blitzcrank50.50% WR
200 games
Worst Picks vs Vayne
These picks are weak against Vayne at many stages of the game. Champs listed by lowest win rate matchups vs Vayne in NA Diamond +.
Lux39.29% WR
112 games
Rell41.84% WR
196 games
Leona42.09% WR
297 games
Pyke44.31% WR
255 games
Pantheon44.64% WR
112 games
Karma44.80% WR
433 games
Yuumi46.70% WR
212 games
Morgana47.55% WR
143 games
Zyra48.21% WR
112 games
Nautilus48.65% WR
407 games
Braum48.86% WR
264 games
Alistar49.02% WR
255 games
Soraka49.07% WR
269 games
Best Lane Counters vs Vayne
These picks counter Vayne during early game laning phase. Highest gold differential at 15 (GD@15) vs Vayne in NA Diamond +.
Pyke119 GD@15
255 games
Karma43 GD@15
433 games
Taric18 GD@15
109 games
Best Late Counters vs Vayne
These picks excel against Vayne in the late game. Highest gold differential at the end of the game vs Vayne in NA Diamond +.