VayneMatchups Spreadsheet
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Optimized Vayne builds, runes, skill orders, and matchup strategies — plus expert tips and guides for every Vayne matchup. Brought to you by League of Matchups, your source for counter-picking insights.
| Matchup | Threat | Games | WR | ADC Gold @ 15 | ADC Gold Diff | Tips | |
|---|---|---|---|---|---|---|---|
 Nami  | Easy | 608 | 49% | -257 | -275 | 💬 No tips yet — Be the first to add a tip! | |
Skill Priority Q Tumble Vayne tumbles, maneuvering to carefully place her next shot. Her next attack deals bonus damage.  W Silver Bolts Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target deals a percentage of the target's max health as bonus true damage.  E Condemn Vayne draws a heavy crossbow from her back, and fires a huge bolt at her target, knocking them back and dealing damage. If they collide with terrain, they are impaled, dealing bonus damage and stunning them. 50.00% WR 570 Matches Summoner Spells  51.48% WR 305 Matches Skill OrderQ Tumble Vayne tumbles, maneuvering to carefully place her next shot. Her next attack deals bonus damage. 1 4 5 7 9 W Silver Bolts Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target deals a percentage of the target's max health as bonus true damage. 2 8 10 12 13 E Condemn Vayne draws a heavy crossbow from her back, and fires a huge bolt at her target, knocking them back and dealing damage. If they collide with terrain, they are impaled, dealing bonus damage and stunning them. 3 14  R Final Hour Readying herself for an epic confrontation, Vayne gains increased Attack Damage, Invisibility during Tumble, reduced Tumble cooldown, and more bonus Move Speed from Night Hunter 6 11                       48.8% WR459 Matches       Starting Items   52.1% WR 288 Matches Core Items   48.8% WR 41 Matches 4th Item Options45.3% WR75 Matches  64.4% WR59 Matches 37.2% WR43 Matches 5th Item Options 56.5% WR23 Matches 45.5% WR22 Matches 55.0% WR20 Matches 6th Item Options 30.0% WR10 Matches 50.0% WR4 Matches 75.0% WR4 Matches Laning Phase (@15 min)Gold Diff-257 XP Diff+282 Ally Ganks2.01 Enemy Ganks2.17 KDA2 / 2 / 2 End of GameTotal Gold Diff-275 Total XP Diff0 KDA7 / 6 / 5 Split Push | |||||||
 Lulu | Easy | 540 | 47% | -378 | -629 | 💬 No tips yet — Be the first to add a tip! | |
 Milio | Easy | 475 | 48% | -162 | -376 | 💬 No tips yet — Be the first to add a tip! | |
 Thresh | Easy | 462 | 50% | -430 | -607 | 💬 No tips yet — Be the first to add a tip! | |
 Karma | Easy | 433 | 55% | -489 | -338 | 💬 No tips yet — Be the first to add a tip! | |
 Nautilus | Easy | 407 | 51% | -441 | -626 | 💬 No tips yet — Be the first to add a tip! | |
 Sona | Easy | 365 | 42% | -350 | -429 | 💬 No tips yet — Be the first to add a tip! | |
 Bard | Easy | 348 | 48% | -117 | +21 | 💬 No tips yet — Be the first to add a tip! | |